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By using a reducible disulfide linker, we built in a redox-sensitive release mechanism to facilitate intracellular release of the unmodified NMDA receptor antagonist, enabling the combined cellular actions of GLP-1 receptor agonism and NMDA receptor antagonism
Upon injection, the PLGA matrix undergoes gradual hydrolysis, releasing the peptide over time
Zhao L, Wang P, Hou HL, Zhang H, Wang YP, Yan SH, Huang Y, Li H, Tan JJ, Hu A et al (2014) Transcriptional regulation of cell cycle genes in response to abiotic stresses correlates with dynamic changes in histone modifications in Maize
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